Reducing the accident risks when driving is one of the current world-wide challenges. Distractions, fatigue, stress affect human reaction time to any external stimuli. The alteration of the reaction time can cause accident and death. Handheld devices can provide assistive solutions to improve the driver attentions and monitor the driver activities. Software and hardware solutions (special focus on human-machine interfaces), use of intelligent safety systems and integrated safety can help in this challenge.